Research funded by the NIHR HTA programme directly influences key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE). NICE is responsible, through technology appraisals, for providing national guidance on new and existing medicines and treatments within England and Wales.The NIHR HTA programme commissions independent Health Technology Assessment reviews to support NICE committees deliver national guidance on new and existing treatments or interventions, and on medical diagnostic technologies to the NHS in England and Wales, through its Technology Appraisals and Diagnostic Assessments respectively.